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The Kimonis Laboratory is a molecular genetics lab within the Division of Genetics & Genomic Medicine at UC Irvine School of Medicine Department of Pediatrics.

We are scientists and doctors studying genetic causes of muscle disease and the natural history of Prader-Willi Syndrome. Dr. Virginia E. Kimonis is particularly interested in inherited muscle disorders that occur in combination with diseases of bone and/or frontotemporal dementia.

Families with a combination of muscle disease and Paget disease of bone have been studied in the laboratory and the gene has been localized to chromosome 9 and identified as VCP (valosin-containing protein). Many families of those suffering from Prader-Willi syndrome have also been recruited.